[SW|ABC transporter]for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein), with [protein|5C52DB31F378E49AABE5D937DD901A68F3810477|YusV] as ATPase
function
[SW|acquisition of iron]
product
[SW|ABC transporter] for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein) [pubmed|28283524]
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
182,370 183,323
The protein
Protein family
Fe/B12 periplasmic-binding domain (according to Swiss-Prot)[SW|Domains]
Two independent non-symmetric globular domains, connected by a long alpha-helix (residues 143-164 of the mature protein).Modification
FeuA is a lipoprotein with a N-acetyl-S-diacyl-glyceryl-cysteine structure [Pubmed|22303020]Structure
[PDB|2PHZ], [PDB|2WI8], [PDB|2WHY] (complex with ferri-bacillibactin)[PDB|2XUZ] (complex with ferri-enterobactin)[PDB|2XV1] (complex with ferric mecam)[SW|Localization]
associated to the membrane (lipoprotein) [Pubmed|22303020]extracellular (signal peptide) [Pubmed|18957862]Expression and Regulation
Operons
genes
[gene|516B13F337FD346B4A4A268E35D1EBABB05957E1|feuA]-[gene|57402D137E3D3791CAF0696421224F4E1DC1BA48|feuB]-[gene|F38F6D4841B3044EA0496B3A1C1D484018BDFEA4|feuC]-[gene|745167427618C4DA71848F9362043B66BC4E392E|ybbA]
description
[Pubmed|12354229]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17725565], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [pubmed|12354229], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon][protein|EB28A65CECE994DF2DF486DEACF40F2533703DB0|Btr]: activation, in the presence of the co-activators bacillibactin or enterobactin [Pubmed|17725565], in [regulon|EB28A65CECE994DF2DF486DEACF40F2533703DB0|Btr regulon]regulation
expression during spore [SW|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]) [pubmed|29133393]expression of the operon is strongly induced at the beginning of [SW|biofilm formation] [pubmed|31113899]additional information
the presence of an iron-responsive element bound by [SW|CitB] between ''[SW|feuA]'' and ''[SW|feuB]'' suggests iron-dependent regulation by [SW|CitB] [Pubmed|10468622]view in new tabOther regulations
[protein|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB]: translation control, Biological materials
Mutant
BKE01630 ([gene|516B13F337FD346B4A4A268E35D1EBABB05957E1|feuA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE01630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATAGAGCCTCCTGTT, downstream forward: _UP4_AACTAATTCAGAGTAGGTTTBKK01630 ([gene|516B13F337FD346B4A4A268E35D1EBABB05957E1|feuA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK01630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATAGAGCCTCCTGTT, downstream forward: _UP4_AACTAATTCAGAGTAGGTTTReferences
20086155,19746494,19673474,14563870,16672620,10092453,16889643,17725565,12354229,18957862,18763711,22303020,10468622,28283524,29133393 
